Synthesis of Lipid Nanoparticles Incorporated with Ferula assa-foetida L. Extract

Solid Lipid Nanoparticles (SLN) have been prepared by high-pressure homogenization and optimized in order to protect ferulic acid from Ferula assa-foetida L. extract. The influence of lipid surfactant concentration on the mean particle size (Z-Ave), polydispersity index (PDI), zeta potential (ZP) SLN was analyzed. In addition, other parameters for preparation acid-loaded nanoparticles, such as extract variable synthesis method used (e.g., pressure), were adjusted obtain smallest index, well highest value potential, which are characteristic stable SLN. established formulation obtained composed 6.0 wt.% phase 1.5 surfactant, giving with Z-Ave, PDI, ZP values 163.00 ± 1.06 nm, 0.16 0.01, −41.97 0.47 mV, respectively. loading within resulted particles a 155.3 1.1 −38.00 1.12 encapsulation efficiency 27%, latter being quantified basis RP-HPLC analysis. Our findings highlight added delivery system phenolic phytochemical compounds extracted